​Selective Cancer Cell Uptake
Time-Lapse of Tumor Targeting with Dye-Drug Conjugates.
Dye Drug Conjugate No. 1
Dye Drug Conjugate No. 2
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Near Infrared (NIR) fluorescent image of colon tumor-bearing mice after a single injection of two of our Dye Drug Conjugates at three different time points.
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Both Dye Drug Conjugates shown above initially have systemic distribution throughout the body at 24 hours. By day 9, the conjugates accumulate specifically within the tumor, with minimal presence in healthy tissues, indicating tumor-specific targeting.
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This selective tumor uptake and clearance from the rest of the body were confirmed by Near Infrared imaging of tumors and organs 17 days after the mice were injected with the above Dye Drug Conjugates.
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NIR fluorescent imaging confirms selective accumulation and prolonged retention of the Dye Drug Conjugate in the tumor 17 days after injection, with stronger fluorescence in the tumor compared to other organs, including the liver. This suggests that Lahjavida's Dye Drug Conjugates not only effectively target tumors, delivering more chemotherapy drugs to the tumor site, but they also avoid healthy tissues.
The Near Infrared (NIR) fluorescent image of the tumor and organs 17 days after the colon tumor-bearing mouse was injected with the Dye Drug Conjugate.
